As devoted caretakers of our feline companions, ensuring their long-term health and happiness is always a top priority. In the realm of nutrition, omega-3 fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) , have garnered significant attention for their numerous health benefits in cats.
Beyond their well-known roles in supporting a healthy coat and cognitive function, EPA and DHA also contribute to your cat's well-being through their influence on inflammatory processes and overall cellular health. Understanding how these fatty acids function can empower you to make informed decisions about your cat's diet and potential supplementation.
Summary
What are EPA and DHA: Essential fatty acids for feline health
Omega-3 fatty acids are a family of polyunsaturated fatty acids, characterized by the presence of a double bond three carbon atoms away from the methyl end of the fatty acid chain. Among these, EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are particularly significant for feline health. These long-chain omega-3 polyunsaturated fatty acids (PUFAs) play vital roles in various physiological processes.
Cats possess a limited capacity to synthesize EPA and DHA from the precursor omega-3 fatty acid alpha-linolenic acid (αLA), which is commonly found in plant-based oils like flaxseed. While the conversion pathway exists, it appears to be more active in nervous tissue, potentially restricting the broader systemic production of EPA and DHA in the liver, which is more common in other mammals. This inefficient conversion underscores the essential nature of directly supplying EPA and DHA in your cat's diet to meet their nutritional needs.
The primary dietary sources of these crucial omega-3 fatty acids are oily fish and fish oil products . Common examples include oils derived from menhaden, cod liver, and salmon. These sources offer a direct and bioavailable form of EPA and DHA, ensuring that your cat can readily access these beneficial nutrients.
While flaxseed oil is a rich source of αLA and is known to increase circulating αLA in cats, its limited conversion to EPA and DHA in felines means it may not be a sufficient sole source for these specific omega-3s.
Understanding how antioxidants work as your cat's natural defense system
Throughout their lives, cats are continuously exposed to free radicals, which are unstable molecules produced during normal metabolism and also from external factors such as environmental pollutants and stress. These molecules possess unpaired electrons, making them highly reactive and capable of damaging vital cellular components, including lipids, proteins, and DNA.
This cellular damage, known as oxidative stress , can contribute to aging and the development of various chronic diseases.
Antioxidants are substances that can counteract the harmful effects of free radicals by neutralizing them. They achieve this by donating an electron to the free radical, stabilizing it without becoming unstable themselves. A sufficient intake of antioxidants is crucial for maintaining the delicate balance within your cat's body and protecting against the damaging consequences of oxidative stress.

Practical ways EPA and DHA improve your cat's wellbeing
Skin health and comfort
Allergic dermatitis is a common issue in cats, often characterized by skin inflammation and associated oxidative stress. Several randomized controlled trials have evaluated the therapeutic effects of EPA and DHA supplementation in dogs with allergic dermatitis, showing significant improvement in clinical signs such as pruritus and erythema.
Although fewer studies focus specifically on cats, one study demonstrated the benefit of an oil preparation with increased n-3 fatty acids on the clinical condition of cats with miliary dermatitis. By helping to modulate the inflammatory response in the skin, EPA and DHA can contribute to healthier skin and alleviate discomfort in your affected cat.
Joint health and mobility support
Osteoarthritis, a degenerative joint disease, involves chronic inflammation and cartilage breakdown, leading to pain and reduced mobility in cats. Research has indicated that diets and supplements enriched with EPA and DHA can help improve clinical signs, behavior, and activity in dogs and cats with osteoarthritis.
A systematic review of nutraceuticals for osteoarthritis in dogs highlighted EPA and DHA as having evident therapeutic benefits. By reducing inflammation within the joints, EPA and DHA can help to alleviate pain and improve the quality of life for your cat if they are suffering from this condition.
Kidney function protection
A study specifically investigating the interaction of dietary betaine and n-3 PUFA (including EPA and DHA from fish oil) in cats found that the combination resulted in a reduction of circulating 3-indoxyl sulfate . This compound is considered a uremic toxin and has been implicated in the progression of kidney disease.
While not directly an antioxidant mechanism, the reduction of this toxin, potentially through positive effects on the gut microbiota and reduced inflammation, suggests a potential benefit of EPA and DHA in supporting your cat's renal health.

Immune system regulation
Enhanced overall vitality
Adding omega-3s to your cat's diet
Finding natural sources in cat food
When and how to use supplements safely
Consider high-quality supplements specifically formulated for cats when looking to boost your cat's omega-3 intake. These supplements can provide concentrated amounts of EPA and DHA in a controlled form, which may be beneficial for cats with specific health conditions or those not consuming enough omega-3s through their regular diet.
Supplements are available in various forms, including liquid and capsules that can be mixed with food or administered directly. Never administer human omega-3 supplements to your cat as the dosages and other ingredients may not be appropriate or safe for felines.

Safety considerations every cat owner should know
Getting the dosage right
Selecting high-quality products
Maximizing omega-3 benefits for your cat's health
EPA and DHA are valuable omega-3 fatty acids that offer significant health benefits for your cat, extending beyond their essential roles to include important influences on inflammatory processes. By helping to manage inflammation, they contribute to your cat's antioxidant defense and support various aspects of feline health, including skin and joint health, and potentially kidney function.
However, it is important to follow proper dosage guidelines when adding EPA and DHA supplements to your cat's diet to ensure they receive the correct and safe amount. Careful attention to quality products and appropriate dosing will allow you to harness the power of these beneficial fatty acids to help your feline companion enjoy a healthier and happier life.
The information in this article is based on the following scientific publications:
Calder, P.C. (n.d.). Omega‐3 polyunsaturated fatty acids and inflammatory processes. [No publisher information provided in the excerpts].
Jewell, D.E. and Jackson, M.I. (2022). Dietary Betaine Interacts with Very Long Chain n-3 Polyunsaturated Fatty Acids to Influence Fat Metabolism and Circulating Single Carbon Status in the Cat. Animals, 12(20), 2837. MDPI.
Leemans, J., Cambier, C., Chandler, T., Billen, F., Clercx, C., Kirschvink, N. and Gustin, P. (2010). Prophylactic effects of omega-3 polyunsaturated fatty acids and luteolin supplementation on allergen-induced inflammation in cats. The Veterinary Journal, 184(1), pp. 111–114. Elsevier Ltd.
Magalhães, T.R., Lourenço, A.L., Gregório, H. and Queiroga, F.L. (2021). Therapeutic Effect of EPA/DHA Supplementation in Neoplastic and Non-neoplastic Companion Animal Diseases: A Systematic Review. in vivo, 35(3), pp. 1419-1436.
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