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Early kidney disease detection that extends your cat's years

Your beloved feline companion may appear perfectly healthy while silently battling an invisible enemy. As your cat purrs contentedly on your lap, a progressive disease might already be affecting their vital organs. Chronic Kidney Disease (CKD) is a prevalent condition in cats, particularly as they advance in age , and it involves a gradual and irreversible decline in the ability of their kidneys to function properly. These vital organs perform a multitude of essential tasks to keep your cat healthy.

The kidneys are responsible for selectively eliminating metabolic waste products from the blood and maintaining the delicate balance of water and ions in the body. Furthermore, they play a crucial role in regulating acid-base balance and have an endocrine function, producing erythropoietin (EPO), a hormone that stimulates red blood cell production, and releasing renin, an enzyme involved in blood pressure regulation. The kidneys are also responsible for converting vitamin D into its active form.

The insidious nature of CKD lies in the fact that in the early stages, most animals show no obvious clinical signs , and therefore their owners may not be aware that there is a problem. This makes early detection a significant challenge for even the most observant pet owners.

The game-changing impact of early detection

Identifying Chronic Kidney Disease in its initial phases, even when symptoms are absent, can dramatically alter the course of the disease for your feline friend. While CKD is a progressive condition that currently has no cure, early diagnosis provides a critical window for interventions aimed at slowing down the rate at which kidney function is lost .

By implementing management strategies early on, you can play a vital role in improving your cat's quality of life. Early interventions can help minimise the clinical signs of uraemia, such as nausea and poor appetite, allowing your cat to feel more comfortable and maintain better overall well-being for a longer period.

Moreover, compelling evidence suggests that dietary intervention in the early stages of CKD can have a substantial positive impact . For example, one study showed that cats with CKD fed a renal diet had a median survival time of 633 days compared to just 264 days for those on a maintenance diet. Furthermore, a smaller proportion of cats on the renal diet died of terminal CKD (47.6%) compared to the maintenance diet group (68.8%).

This underscores that the earlier CKD is identified, the more effective treatment and management strategies, particularly dietary modifications, can be in influencing the disease's progression and outcome.

Fluffy cream-colored cat relaxing on a soft beige rug in a cozy, well-lit room

Decoding the whispers: Recognizing subtle early signs

While early-stage CKD often presents with a lack of overt symptoms, your keen observation might reveal subtle changes in your cat's habits. One of the earliest and most common signs is increased thirst, also known as polydipsia, which often leads to increased urination, or polyuria .

You may notice your cat visiting the water bowl more frequently or for longer periods, and the litter box might need more frequent cleaning due to larger volumes of urine. Pay close attention to whether your cat starts urinating more frequently during the night (nocturia), as this can also be an early indicator.

Another subtle sign to watch for is gradual weight loss . This can be particularly challenging to notice if it occurs slowly over time, and it might happen even if your cat's appetite appears relatively normal initially. You might also observe subtle changes in appetite, such as a slight decrease in the overall amount of food consumed or your cat becoming more selective or finicky about what they eat.

It is important for you to distinguish these often overlooked early signs from the more apparent symptoms that tend to manifest as the disease progresses. Later signs can include lethargy, a more significant loss of appetite, vomiting, more pronounced weight loss, and even halitosis (bad breath) due to uraemia. Recognizing these subtle whispers of early CKD can prompt timely veterinary intervention, significantly impacting your cat's future health.


Veterinary detection methods: The diagnostic toolkit

Early detection of CKD relies on proactive measures taken during routine veterinary check-ups, especially for cats as they enter their senior years, generally around 7 years and older. Regular veterinary visits are crucial, even if your cat appears healthy , as these appointments provide an opportunity for your veterinarian to perform key diagnostic tests that can uncover early kidney dysfunction.

Standard diagnostic procedures often include blood tests, which measure various kidney function markers such as creatinine and blood urea nitrogen (BUN). However, it's important for you to understand that in the very early stages of CKD (IRIS Stage 1), serum creatinine concentrations may still fall within the normal reference interval. Therefore, relying solely on creatinine levels might not always identify CKD in its earliest phases.

Urine tests play a vital role in early detection . Urine specific gravity (USG) assesses your cat's kidneys' ability to concentrate urine. In the early stages of kidney damage, this concentrating ability can be impaired, leading to a lower USG.

Another important urine test is the urine protein to creatinine (UPC) ratio, which helps detect protein in the urine. Proteinuria can be an early indicator of kidney damage, even before significant changes in blood creatinine are evident.

Additionally, newer renal biomarkers, such as Symmetric Dimethylarginine (SDMA) , are becoming increasingly utilized and can sometimes detect a decline in kidney function earlier than traditional markers like creatinine. In some cases, if there is suspicion of underlying kidney abnormalities, your veterinarian might recommend diagnostic imaging, such as ultrasound or X-rays of the kidneys, to assess their size, shape, and internal structure.

Fluffy grey cat looking at a clear glass bowl of water placed on the floor by a woman in a blue sweater

After diagnosis: Managing early CKD effectively

Receiving an early diagnosis of Chronic Kidney Disease in your cat is the first step towards proactive management. Following diagnosis, your veterinarian will develop an individualized management plan tailored to your cat's specific stage of CKD and their unique needs.

A cornerstone of early CKD management is often dietary modification . Specialized renal diets are formulated to be lower in protein and phosphorus, and often supplemented with omega-3 fatty acids and antioxidants, which can help manage the disease and potentially slow its progression.

Owner involvement is absolutely key to the successful management of CKD . You will need to commit to following the dietary recommendations, administering any prescribed medications, and diligently monitoring your cat for any changes in their clinical signs, such as appetite, water intake, urination habits, and overall activity levels.

Your cat with CKD requires regular follow-up veterinary visits to assess their condition, repeat diagnostic tests (including blood and urine analyses), and make any necessary adjustments to the treatment plan. These check-ups may also include monitoring your cat's blood pressure, as systemic hypertension is a common complication in cats with CKD.

Early diagnosis allows for the implementation of these management strategies before the disease progresses significantly, offering the best chance for maintaining your cat's health and well-being.

Making a difference: Your role in early detection and management

Early detection of Chronic Kidney Disease holds immense significance for the health and longevity of your beloved feline companion. By recognizing the subtle early signs and understanding the diagnostic tools available to your veterinarian, you can play a proactive role in managing this common condition.

Be vigilant in observing any changes in your cat's behavior and habits , particularly their water intake and urination frequency. Schedule regular veterinary check-ups for your feline friends, especially as they enter their senior years , as proactive screening is the most effective way to identify CKD in its initial, more manageable stages.

Remember, while CKD is a progressive disease, early awareness and timely action can make a profound difference in the lives of cats affected by this condition, helping them enjoy a better quality of life and potentially extending the precious time you have together.



Dr. Annina Müller, a veterinarian in clinical attire examining an exotic pet, demonstrating her expertise in specialized veterinary care with a professional and compassionate approach to animal treatment.

Dr. Annina Müller

Dr. Annina Müller earned her veterinary degrees in Switzerland before gaining diverse experience with companion and farm animals, shelter projects, and wildlife sanctuaries, now specializing in exotic pets while maintaining particular interests in wildlife medicine and feline care.

The information in this article is based on the following scientific publications:

  • Martos, C.M.P. (2014). Chronic_kidney_disease_Martos.pdf. University of Córdoba.

  • Marino, C.L., Lascelles, B.D.X., Vaden, S.L., Gruen, M.E. and Marks, S.L. (2014). Prevalence and classification of chronic kidney disease in cats randomly selected from four age groups and in cats recruited for degenerative joint disease studies. Journal of Feline Medicine and Surgery, 16(6), pp. 465-472.

  • Nealon, N.J., Summers, S., Quimby, J. and Winston, J.A. (2024). Untargeted metabolomic profiling of serum from client‑owned cats with early and late‑stage chronic kidney disease. Scientific Reports, 14(1), p. 5831.

  • White, J.D., Malik, R. and Norris, J.M. (2011). Feline chronic kidney disease: Can we move from treatment to prevention? The Veterinary Journal, 190(3), pp. 317-322.


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