Many cat owners struggle with their feline companions experiencing significant anxiety during carrier trips or veterinary visits. Feline stress is a widespread issue that manifests in various ways, affecting both health and behavior. Recognizing and managing this stress is crucial for ensuring a happy and healthy life for your beloved pet. Could there be a natural solution to ease your cat's anxiety? Enter alpha-casozepine, a natural supplement that may hold the key to calming your cat's nerves. In this post, we'll explore what alpha-casozepine is, how it works, and whether it could be the key to a calmer, happier cat.
What is alpha-casozepine?
Alpha-casozepine is a bioactive peptide derived from milk protein. Specifically, it is a tryptic hydrolysate of bovine α-s1 casein. This means it's a protein fragment obtained from cow's milk that has specific properties that can help manage stress. It is worth noting that in Austria, veterinarians sometimes administer bovine α-s1 casozepine.
For pet owners concerned about the safety of their cats, alpha-casozepine is classified as a nutraceutical food, so it's generally considered safe and has no addiction potential . This makes it a potentially attractive option for managing feline stress without the concerns associated with some pharmaceutical interventions.
How alpha-casozepine works to reduce stress
Alpha-casozepine's calming effects are linked to its interaction with GABA receptors in the brain . GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the central nervous system. It plays a crucial role in reducing neuronal excitability throughout the nervous system.
By interacting with GABAA receptors, alpha-casozepine enhances the effect of GABA, promoting relaxation and reducing anxiety. This mechanism of action gives it calming and anti-anxiety properties. Studies have shown that alpha-casozepine can lead to reduced anxiety behaviors and serum cortisol levels in anxious dogs. Furthermore, it may also improve your cat's relationship with people, making them more comfortable and sociable around you and your family.

The science behind alpha-casozepine and feline stress
To evaluate the effectiveness of alpha-casozepine on feline stress, researchers conducted a study focusing on cats visiting veterinary practices. Sixty adult cats participated in a randomized, placebo-controlled study. The cats were divided into three groups to test different dosages: a low dose group (15 mg/kg), a high dose group (75 mg/kg), and a placebo group. The study involved two veterinary checkups, one without treatment and another four weeks later with alpha-casozepine or a placebo administered before the second visit.
The key findings of this study shed light on alpha-casozepine's impact on feline stress responses:
Sweaty Paws: one of the most significant findings was the absence of sweaty paws in cats treated with the high dose of alpha-casozepine . This observation was made both in the waiting area and the examination room of the veterinary practice. Sweaty paws are a physiological indicator of stress, suggesting that alpha-casozepine can help reduce the physical manifestations of anxiety in your cat when they're feeling nervous.
Autonomic Nervous System: overall, alpha-casozepine appears to influence the autonomic nervous system, which controls many involuntary functions in the body. By modulating the autonomic nervous system, alpha-casozepine can help your cat better cope with stressful situations that would typically trigger anxiety.
The findings suggest that alpha-casozepine can be a valuable tool in managing feline stress, particularly in reducing physical signs of anxiety.

How to effectively administer calming supplements for cats
Calming supplements can be highly beneficial in helping cats manage stress caused by situations such as vet visits, travel, environmental changes, or the introduction of new people or pets in the household. These events can trigger anxiety, and the right supplement can help promote relaxation and ease discomfort.
For optimal effectiveness , calming supplements should be administered regularly as part of your cat’s daily routine, rather than only before stressful events. A consistent regimen supports a balanced mood and reduces sensitivity to anxiety triggers. By integrating a calming supplement into your cat’s everyday care, they will be better prepared to handle both expected and unexpected stressors, ensuring overall well-being.
Thanks to their liquid formulation , these supplements offer a simple and stress-free administration method, making them ideal for cats that resist pills or capsules. Here are the most effective ways to give them to your cat:
Directly into the mouth : use a dropper or a syringe (without a needle) to gently dispense the solution into your cat’s mouth.
Mixed with food : add the recommended amount to your cat’s wet food or a small portion of an appetizing meal.
On a treat : soak a treat your cat loves to encourage natural intake.
By using a consistent and easy-to-administer approach , calming supplements can help maintain your cat’s emotional balance and improve their ability to cope with stress.
Complementary stress management strategies
While alpha-casozepine can be a helpful tool, it's most effective when combined with other stress-reducing strategies . Creating a calming environment and routine can significantly improve your cat's overall well-being.
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Environmental Enrichment:
Provide a stimulating and safe environment for your cat to explore and enjoy.
Offer scratching posts, toys, and climbing opportunities to keep your cat mentally and physically engaged throughout the day.
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Consistent Routine:
Cats thrive on routine, so keep feeding schedules and litter box maintenance consistent.
Predictability helps your cat feel more secure and reduces anxiety about what might happen next.
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Calming Signals:
Use slow blinks to reassure your cat when they seem anxious or uncertain.
Slow, deliberate movements and a calm tone of voice can also help create a relaxing atmosphere for your nervous feline.
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Safe Spaces:
Ensure your cat has access to quiet, secure spots where they can retreat when feeling overwhelmed .
These safe havens can be as simple as a cardboard box, a quiet corner, or a high perch where your cat can observe their surroundings safely.

Conclusion
Alpha-casozepine helps reduce stress in cats by influencing the autonomic nervous system and reducing the physical signs of anxiety. While alpha-casozepine shows promise, remember that it's not a one-size-fits-all solution. By combining alpha-casozepine with other stress-reducing strategies, you can help your cat live a happier, more relaxed life. Creating a calm and predictable environment, providing plenty of enrichment, and understanding your cat's individual needs are all essential components of effective stress management. With the right approach, you can help your feline friend navigate life's challenges with greater ease and comfort.
The information in this article is based on the following scientific publications:
Braastad, B.O., McBride, A. and Newberry, R.C. (2022). The cat behaviour and welfare. CAB International.
Fan, Z., Bian, Z., Huang, H., Liu, T., Ren, R., Chen, X., Zhang, X., Wang, Y., Deng, B. and Zhang, L. (2023). Dietary Strategies for Relieving Stress in Pet Dogs and Cats. Antioxidants, 12(3), 545.
Guazzelli Pezzali, J. (2023). Functional Amino Acids in Dogs and Cats: Implications for Overall Health. J. Anim. Sci, 101, Suppl. S3.
Makawey, A., Iben, C., Palme, R. (2020). Cats at the Vet: The Effect of Alpha-s1 Casozepin. Animals, 10, 2047.
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