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Calico cat with golden eyes lying peacefully, illustrating feline well-being and the benefits of omega-3s for cat health

How EPA and DHA omega-3s can transform your cat's health: 5 science-backed benefits

As loving cat owners, you want your feline companions to live long, healthy lives. When your cats face health challenges—from itchy skin and stiff joints to more serious conditions—you naturally seek ways to support their well-being. Understanding essential nutrients like omega-3 fatty acids, particularly EPA and DHA , becomes crucial in this journey. Recent research reveals the valuable role these specialized fats can play in managing common feline ailments. This article explores what EPA and DHA are and how their supplementation might offer therapeutic benefits for your cat, based on current scientific evidence.

Understanding EPA and DHA: Essential building blocks for your cat's health

What are EPA and DHA?

EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) are omega-3 polyunsaturated fatty acids (PUFAs) . Think of fatty acids as the fundamental building blocks of fats, with PUFAs possessing specific chemical structures that give them their unique therapeutic properties. While some animals can efficiently synthesize EPA and DHA from plant-based alpha-linolenic acid (ALA), your cat has a limited ability to perform this conversion . This means your feline companion must obtain EPA and DHA directly from their diet.

Where to find EPA and DHA: natural marine sources

The primary sources of EPA and DHA are fish and fish-oil products , including oils derived from menhaden, cod liver, and salmon. Other marine sources such as crab, lobster, oysters, mussels and squid, and marine algae also provide rich concentrations of these beneficial fats. Because your cat requires direct consumption of these nutrients, ensuring their diet or supplements contain adequate amounts of EPA and DHA is essential for supporting their optimal health.

Five proven therapeutic benefits for your cat's health

Let me walk you through the specific conditions where EPA and DHA supplementation has demonstrated promise or proven benefits for your cat.

1. Joint comfort and mobility: addressing osteoarthritis naturally

Osteoarthritis , characterized by inflammation and joint degeneration, commonly affects older cats. This painful condition leads to discomfort, stiffness, and reduced activity, significantly impacting your cat's ability to jump, play, and move freely. Fortunately, EPA and DHA supplementation has demonstrated clear therapeutic benefits for feline osteoarthritis.

Clinical studies examining cats with osteoarticular conditions indicate that supplementing with EPA and DHA can markedly improve clinical signs, behavior, activity levels, and even orthopedic measurements . A comprehensive systematic review of companion animal studies found that EPA and DHA provided evident therapeutic benefit for osteoarthritis management.

While these fatty acids are often included in specialized joint support diets alongside ingredients like glucosamine and chondroitin, the evidence strongly suggests that omega-3s, particularly EPA and DHA, serve as the key drivers of the positive effects you'll observe. The overall body of evidence supports considering long-chain omega-3 fatty acids as an important component in managing your cat's osteoarthritis.

2. Skin wellness: managing allergic reactions and inflammation

Feline allergic dermatitis encompasses a range of skin diseases caused by hypersensitivity reactions to allergens such as flea bites, food components, or environmental factors. This frustrating condition is characterized by intense itching, leading to excessive scratching, hair loss, lesions, and crusts on your cat's skin. Managing allergic dermatitis can be particularly challenging, making dietary interventions a valuable component of a multi-modal treatment approach.

EPA and DHA supplementation shows genuine potential for managing these distressing skin symptoms in your feline companion. One targeted study examining cats diagnosed with miliary dermatitis —a common pattern presenting as tiny crusty bumps—found significant clinical improvement after supplementation with EPA and DHA-enriched oil. This research suggests that these fatty acids may effectively reduce skin inflammation and its associated signs.

3. Respiratory support: reducing airway inflammation

Chronic or excessive inflammation can contribute significantly to respiratory diseases in your cat. Omega-3 fatty acids are known to influence inflammatory pathways throughout the body, and increasing dietary EPA and DHA intake is expected to help reduce systemic inflammation in your feline companion.

One notable study utilizing an experimental model of allergen-induced airway inflammation in cats explored the therapeutic potential of omega-3 PUFAs. The research findings suggested that dietary omega-3 PUFAs, especially when combined with compounds like luteolin, may help prevent the increased airway responsiveness that occurs during inflammatory episodes.

Airway responsiveness refers to how easily your cat's airways constrict—a key feature of asthma-like conditions. While this was an experimental study, it highlights EPA and DHA's potential role in modulating airway inflammation, thereby supporting respiratory wellness in cats who are susceptible to allergen-induced inflammation.

4. Kidney protection: supporting long-term renal health

Kidney disease unfortunately affects many older cats , making dietary management a crucial component in supporting your cat's kidney function. Current research actively explores how specific nutrients can influence kidney health markers and overall renal wellness. One significant study found that combining dietary betaine with fish oil (a rich source of EPA and DHA) resulted in a measurable reduction of circulating 3-indoxyl sulfate —a compound considered a renal toxin that can be harmful to your cat's kidneys. This reduction suggests positive effects on kidney health, possibly achieved through beneficial influences on gut bacteria.

Furthermore, a retrospective study provided valuable insights into diet's long-term impact on cats with chronic renal insufficiency. This research revealed that cats fed specialized kidney diets (which often contain higher EPA content) had significantly longer survival times compared to those fed conventional diets.

While retrospective studies provide weaker evidence than randomized controlled trials, and kidney diets likely differed in multiple nutritional aspects beyond EPA content alone, this finding underscores the potential importance of dietary EPA and DHA in supporting your cat's kidney health throughout their senior years.

5. Urinary tract wellness: preventing painful stone formation

Urinary stones, particularly calcium oxalate stones , can cause significant pain and serious health complications for your cat. Various dietary factors can influence the risk of stone formation in your feline companion's urinary tract. One important study examining dietary long-chain PUFAs found that increased EPA and DHA consumption reduced risk of calcium oxalate stone formation . This finding adds yet another potential benefit to the ways EPA and DHA can positively impact your cat's health by influencing urine composition in a manner that reduces the likelihood of certain stone types developing.

Your step-by-step guide to safe EPA and DHA supplementation

If you're considering EPA and DHA supplementation for your cat, I recommend following these essential guidelines to ensure safe and effective implementation:

Selecting the right supplement form for your cat

EPA and DHA can be incorporated through specially formulated therapeutic cat foods designed for specific conditions, or they can be administered as dedicated supplements available in oil or capsule forms.

Maintaining consistency for optimal results

Like most nutritional interventions, realizing the potential benefits of EPA and DHA supplementation requires consistent daily administration over an extended period . You shouldn't expect overnight results; instead, discuss with your veterinarian how long it might take to observe meaningful improvements in your cat's condition.

Monitoring your cat's response to supplementation

After initiating supplementation, pay close attention to your cat's overall condition and carefully note any changes you observe, whether positive or concerning. Make sure to report these observations to your veterinarian during scheduled follow-up visits.

Working with your pet health expert for optimal feline wellness

EPA and DHA are vital omega-3 fatty acids for your cat's wellbeing, primarily obtained from fish and fish oil sources. Current research highlights several important areas where supplementing your cat's diet with these nutrients can offer significant therapeutic advantages. From supporting joint health and improving mobility in cats suffering from osteoarthritis, to potentially helping manage skin inflammation, influencing airway inflammation, assisting with kidney function support, and reducing urinary stone formation risk, the scientific evidence is compelling and continues to grow .

While some studies do have limitations and additional research will always be beneficial, the existing data strongly support EPA and DHA's value for maintaining and improving your cat's health. If you believe your feline companion could benefit from this type of nutritional support, I encourage you to have an open, detailed conversation with your pet health expert . They can help you navigate the available options and create a personalized supplementation plan that incorporates EPA and DHA as part of your cat's comprehensive health strategy. By working collaboratively with your pet health expert, you can help your beloved cat achieve and maintain their healthiest possible life.


Dr. Ingrid De Wet, a veterinarian in professional clinical attire, providing compassionate care to a small animal patient while consulting with a pet owner, demonstrating her expertise in personalized veterinary medicine.

Dr. Ingrid De Wet

Dr. De Wet brings 15 years of small animal expertise to personalized veterinary care through in-clinic work and emergency teleconsultations, contributing to pet health education while drawing on personal experience as a pet owner to understand the emotional and practical aspects of pet healthcare.

The information in this article is based on the following scientific publications:

  • Jewell, D.E. and Jackson, M.I. (2022). Dietary Betaine Interacts with Very Long Chain n-3 Polyunsaturated Fatty Acids to Influence Fat Metabolism and Circulating Single Carbon Status in the Cat. Animals.

  • Leemans, J., Cambier, C., Chandler, T., Billen, F., Clercx, C., Kirschvink, N. and Gustin, P. (2010). Prophylactic effects of omega-3 polyunsaturated fatty acids and luteolin on airway hyperresponsiveness and inflammation in cats with experimentally-induced asthma. The Veterinary Journal.

  • Magalhães, T.R., Lourenço, A.L., Gregório, H. and Queiroga, F.L. (2021). Therapeutic Effect of EPA/DHA Supplementation in Neoplastic and Non-neoplastic Companion Animal Diseases: A Systematic Review. 


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